I recently had the opportunity of recording a podcast episode for the Virtual Critical Care Rounds (VCCR) of the Society of Critical Care Medicine (SCCM) with Sean Kane, PharmD, BCPS (@ClinCalc). We discussed the nuances of acetaminophen toxicity and practical application of the Rumack-Matthew nomogram in the clinical setting.
You can find the link to the podcast episode here (as well as other episodes of the SCCM VCCR).
Some suggested references for the episode are below for review and further reading:
Lin M. Paucis Verbis: Acetaminophen Toxicity. Academic Life in Emergency Medicine (ALiEM). Available at: https://www.aliem.com/2011/11/paucis-verbis-acetaminophen-toxicity/
Sarchi A, Carroll S. Acetaminophen Overdose. EM Basic. Available at: http://embasic.org/acetaminophen-overdose/
Hayes BD. Utility of Pre-4-Hour Acetaminophen Level in Acute Overdose. ALiEM. Available at: https://www.aliem.com/2015/08/utility-of-pre-4-hour-acetaminophen-levels-in-overdoses/
Hayes BD. Are Acetaminophen Levels Necessary in All Overdose Patients? ALiEM. Available at: https://www.aliem.com/2013/09/are-acetaminophen-levels-necessary-in-all-overdose-patients/
Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol 2002; 40(1):3-20.
Hodgman MJ, Garrard AR. A review of acetaminophen poisoning. Crit Care Clin 2012; 28(4):499-516.
Dougherty PP, Klein-Schwartz W. Unexpected late rise in plasma acetaminophen concentrations with change in risk stratification in acute acetaminophen overdoses. J Emerg Med 2012; 43(1):58-63.
Kirschner RI, Rozier CM, Smith LM, Jacobitz KL. Nomogram line crossing after acetaminophen combination product overdose. Clin Toxicol 2016; 54(1):40-6.
ACMT Position Statement: Duration of Intravenous Acetylcysteine Therapy Following Acetaminophen Overdose. J Med Toxicol 2017; 13(1):126-127.
Gosselin S, Juurlink DN, Kielstein JT, et al. Extrip Workgroup.
Extracorporeal treatment for acetaminophen poisoning: recommendations
from the EXTRIP workgroup. Clin Toxicol 2014; 52(8):856-867.